Warning: SPOILERS below for Avengers: Endgame and Marvel's Agents of S.H.I.E.L.D. season 6 premiere. How does Marvel's Agents of S.H.I.E.L.D. season 6 address the events of Thanos' Decimation snap and Avengers: Endgame? At the conclusion of Agents of S.H.I.E.L.D. season 5, the team led by Phil Coulson fought off an alien invasion by the Confederacy, who were demanding Gravitonium and Inhumans in exchange for protection from Thanos. Key moments in S.H.I.E.L.D. season 5's final episodes even lined up with Avengers: Infinity War's attack of New York by the Black Order in the MCU timeline. However, as every Marvel fan is aware, Thanos won and killed half of all life in the universe with the Infinity Gauntlet.