Scientists create new map of brain's immune system

MedicalXpress - 02-20

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A team of researchers under the direction of the Medical Center—University of Freiburg has created an entirely new map of the brain's own immune system in humans and mice. The scientists demonstrated for the first time that phagocytes in the brain, the so-called microglia, all have the same core signature but adapt in different ways depending on their function. It was previously assumed that these are different types of microglia. The discovery, made by means of a new, high-resolution method for analyzing single cells, is important for the understanding of brain diseases. Furthermore, the researchers from Freiburg, Göttingen, Berlin, Bochum, Essen, and Ghent (Belgium) have demonstrated in detail how the human immune system in the brain changes in the course of multiple sclerosis (MS), which is significant for future therapeutic approaches. The study was published on 14 February 2019 in the journal Nature.